![]() The cross-reactivity between milk proteins from different animal species has been studied. Knowledge of cross-reactivity allows for better management of allergic load, and the use of fewer antigens in objective testing and immunotherapy.Ĭross-reactivity between milk allergens from different mammalian species and humans occurs when they share part of their amino acid sequence or when they have a similar capacity to bind specific antibodies due to their molecular structures. Food cross-reactivities are not well understood and there has been a recent change in their emphasis. Latex represents an example of a collage of antigens to which some latex-sensitive individuals have reported a significant incidence of concomitant food sensitivity. This last example has been called concomitant food sensitivity. 23 Patients may be more symptomatic during ragweed season when consuming cantaloupe, adding to their critical allergic load. Other associations described have included ragweed and some melons or bananas for example. Foods may cross-react with inhalants as in the oral allergy syndrome described later. Foods may also cross-react with other foods such as within the families of grains. Seemingly different antigens within families may substantially cross-react, such as with timothy and rye grass, or there may be a weaker cross-reactivity, such as with timothy and Johnson grass. Cross-reactivity may be robust among antigens of similar phylogeny such as different types of oak trees or ragweeds. The two antigens in question have similar three-dimensional structural regions, known as epitopes, which allow the antibody for one antigen to recognize a second antigen as being structurally the same antigen. CHADWICK MD, FACS, FAAOA, in Managing the Allergic Patient, 2008 Cross-reactivityĬross-reactivity between antigens occurs when an antibody directed against one specific antigen is successful in binding with another, different antigen. ![]()
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